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fluoride toxicity
Although safe and even healthy at low concentrations, sustained consumption of large amounts of soluble fluoride salts is dangerous. Referring to a common salt of fluoride, sodium fluoride (NaF), the lethal dose for most adult humans is estimated at 5 to 10 g (which is equivalent to 32 to 64 mg/kg elemental fluoride/kg body weight). Ingestion of fluoride can produce gastrointestinal discomfort at doses at least 15 to 20 times lower (0.2–0.3 mg/kg or 100 to 150 mg for a 50 kg person) than lethal doses. Although helpful for dental health in low dosage, chronic exposure to fluoride in large amounts interferes with bone formation. In this way, the most widespread examples of fluoride poisoning arise from consumption of ground water that is abnormally fluoride-rich.
==Recommended levels of fluoride==
For optimal dental health, the World Health Organization recommends a level of fluoride from 0.5 to 1.0 mg/L (milligrams per litre), depending on climate. Adverse effects become possible at fluoride levels far above this recommended dosage. The United States Health and Human Services Department recommends 0.7 milligrams of fluoride per liter of water – the lower limit of the current recommended range of 0.7 to 1.2 milligrams.〔http://www.reuters.com/article/2011/01/08/us-usa-fluoride-idUSTRE7064CM20110108〕
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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